Abstract Given that hypoxia is a persistent physiological feature of many different solid tumors and a key driver for cancer malignancy. it is thought to be a major target in cancer treatment recently. Tumor-associated macrophages (TAMs) are the most abundant immune cells in the tumor microenvironment (TME). which have a large impact on tumor development and immunotherapy. https://www.marcelovicente.com/product-category/thrill/