Abstract Background p27Kip1 plays a major role as a negative regulator of the cell cycle. The regulation of p27Kip1 degradation is mediated by its specific ubiquitin ligase subunits S-phase kinase protein (Skp) 2 and cyclin-dependent kinase subunit (Cks) 1. However. little is known regarding the prognostic utility of p27Kip1. https://www.petsafewirelessfence.com/product-category/air-freshener-disp-refills/